Catalog Number - 85318-PG2

The 85318‑PG2 Cogent RP C18 ABX™ Guard Column Cartridges are engineered to extend analytical column life while maintaining high‑efficiency separations, protecting against particulates, matrix contaminants, and strongly retained compounds.

Packed with 3 µm RP C18 ABX™ stationary phase, these cartridges use bulky end‑capped, high‑purity silica bonding, ensuring stable chromatographic performance across extreme pH conditions (2–12).

Designed for Analytical Columns (3.0–4.6 mm ID)

• Compatible with:

  • 3.0 mm ID solvent‑saving columns

  • 4.0 mm ID analytical columns

  • 4.6 mm ID standard HPLC columns

✅ Maintains method consistency and chromatographic selectivity

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained acidic and basic analytes

  • Sample matrix fouling and buildup

• Extend column lifetime

• Maintain retention reproducibility and peak shape

• Reduce downtime and replacement costs

3 µm Guard Media – High‑Efficiency Analytical Protection

• Matches high‑efficiency analytical column particle sizes

• Preserves resolution and peak integrity

• Ideal for method development, QC, and regulated workflows

✅ Provides maximum protection with minimal impact on chromatographic performance

Why Choose RP C18 ABX™ Guard Cartridges (3 µm)

Matched Extreme pH Chemistry

• Same ABX™ stationary phase as analytical column

• Maintains retention behavior and selectivity

• Ensures method reproducibility across pH 2–12

Enhanced Column Protection

• Traps contaminants before reaching the analytical column

• Reduces irreversible adsorption and degradation

Workflow Efficiency

• Minimizes column replacement frequency

• Improves analytical system uptime

Cogent RP C18 ABX™ Advantages

Extreme pH Stability

• Reliable performance across pH 2–12

• Ideal for acidic and basic compound analysis

Bulky End‑Capping

• Reduces secondary interactions

• Enhances peak symmetry and reproducibility

Durable Construction

• Stainless steel cartridge body

• Stainless steel frits

• PEEK frit caps

✅ Designed for long‑term reliability in analytical environments

Important Usage Notes

• ⚠️ Must be used with a compatible guard column holder system

• Designed for analytical HPLC systems (3.0–4.6 mm ID columns)

• Suitable for extreme pH workflows (pH 2–12)

• Replace regularly to maintain optimal chromatographic performance

Helpful Resource & Link

• 👉 View guard column holders and compatibility options for these cartridges